Latest in: R&D Updates
September 9, 2026
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4 min read

Leyden Labs Reports Positive Phase 1 Results for RIG-101, Supporting Advancement into Phase 2 to Protect Asthma Patients

Leyden Labs reports positive Phase 1 results for RIG-101, an investigational intranasal therapy designed to strengthen antiviral defenses and help prevent virus-triggered asthma exacerbations. The results support RIG-101’s advancement into Phase 2 clinical development.
February 4, 2026
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3 min read

Leyden Labs Demonstrates Feasibility of Novel Antibody-Based Nasal Spray for Flu Prevention

In a new paper published in Science Translational Medicine, Leyden Labs reports landmark preclinical and clinical data supporting the development of their antibody-based nasal sprays to prevent influenza infection by neutralizing virus at portal …
April 7, 2025
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5 min read

Leyden Labs Publishes New Data Confirming Potential of Intranasal Antibody Approach

In vivo influenza protection was achieved at a significantly lower antibody dose with intranasal compared to systemic administration  In contrast to what is observed with systemic administration, Leyden Labs’ lead influenza antibody CR9114 has …
February 16, 2024
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1 min read

New publication shows CR9114 protects against avian flu in mice

The ongoing spread of avian flu among animals has increased the urgency of developing products that could prevent infection in the event of an H5N1 pandemic.
April 19, 2023
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2 min read

Leyden Labs’ Intranasal PanFlu Antibody Enters the Clinic

Leyden Laboratories B.V., (the “Company” or “Leyden Labs”) announced today the dosing of the first Phase 1 healthy volunteer cohort with a nasal spray containing PanFlu candidate CR9114. CR9114 is a universal anti-hemagglutinin stem …
February 4, 2023
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1 min read

Modeling Covid vaccination strategies for endemic SARS-CoV-2

A new article from Leyden Labs has been published in the European Journal of Epidemiology.
November 2, 2022
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1 min read

New publication highlights the secret to CR9114’s pan-influenza protection

Recently, our article entitled “The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection,” appeared in a special issue of Frontiers in Virology on the role of genetic and …
October 30, 2022
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1 min read

Population modeling reveals impact of antibody nasal sprays on new viruses like SARS-CoV-2

A new research article by Leyden Labs and partners at Imperial College has been published in Infectious Diseases & Therapy.
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